Peripheral NKT cells in simian immunodeficiency virus-infected macaques

CS Fernandez; AC Chan; K Kyparissoudis; R De Rose; DI Godfrey; SJ Kent

Journal article

Peripheral NKT cells in simian immunodeficiency virus-infected macaques

CS Fernandez, AC Chan, K Kyparissoudis, R De Rose, DI Godfrey, SJ Kent

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2009

DOI: 10.1128/JVI.02138-08

Abstract

NKT cells are a specialized population of T lymphocytes that have an increasingly recognized role in immunoregulation, including controlling the response to viral infections. The characteristics of NKT cells in the peripheral blood of macaques during simian immunodeficiency virus (SIV) or chimeric simian/human immunodeficiency virus (HIV) (SHIV) infection were assessed. NKT cells comprised a mean of 0.19% of peripheral blood lymphocytes across the 64 uninfected macaques studied. Although the range in the percentages of NKT cells was large (0 to 2.2%), levels were stable over time within individual macaques without SIV/SHIV infection. The majority of NKT cells in macaques were CD4 + (on avera..

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University of Melbourne Researchers

Rob De Rose Author

Dale Godfrey Author

Stephen Kent Author

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Awarded by Medical Research Council

Funding Acknowledgements

[ "We thank Sheilajen Alcantara, Roberta Goli, Kellie Frost, and Stuart Berzins for expert assistance and advice.", "This work was supported by Australian National Health and Medical Research Council awards 454363, 454569, and 299907." ]